Salivary Gland Cancer

Expert-reviewed information summary about the treatment of salivary gland cancer.Salivary Gland Cancer (PDQ®): TreatmentSalivary Gland Cancer Treatment

General Information About Salivary Gland Cancer

Salivary gland cancer is a rare disease in which malignant (cancer) cells form in the tissues of the salivary glands.

The salivary glands make saliva and release it into the mouth. Saliva has enzymes that help digest food and antibodies that help protect against infections of the mouth and throat. There are 3 pairs of major salivary glands:


Parotid glands: These are the largest salivary glands and are found in front of and just below each ear. Most major salivary gland tumors begin in this gland.
Sublingual glands: These glands are found under the tongue in the floor of the mouth.
Submandibular glands: These glands are found below the jawbone.

There are also hundreds of small (minor) salivary glands lining parts of the mouth, nose, and larynx that can be seen only with a microscope. Most small salivary gland tumors begin in the palate (roof of the mouth).

More than half of all salivary gland tumors are benign (not cancerous) and do not spread to other tissues.



Being exposed to certain types of radiation may increase the risk of salivary cancer.

Anything that increases the chance of getting a disease is called a risk factor. Although the cause of most salivary gland cancers is not known, risk factors include the following:


Older age.
Treatment with radiation therapy to the head and neck.
Being exposed to certain substances at work.